The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000 - 1/2000. Detects a band of approximately 52 kDa (predicted molecular weight: 52 kDa).
FunctionReceptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: Participates to NRTN-induced 'Ser-727' phosphorylation of STAT3.
Tissue specificityIsoform 1 is found in both brain and placenta.