Biological descriptionSelective Hsp90 inhibitor. Binds the ATP site of Hsp90 and inhibits chaperone activity. A benzoquinone ansamycin antibiotic. Also inhibits the Hsp90 paralog GRP94. Exhibits various cellular actions including gene expression, cell proliferation, apoptosis and angiogenesis.
Chemical name9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate
Storage instructionsStore at -20°C. Store at -20°C long term. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Lee CH et al. Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. Biochimie94:1382-9 (2012).
Read more (PubMed: 22445681) »
Roe SM et al. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem42:260-6 (1999).
Read more (PubMed: 9925731) »
Whitesell L et al. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A91:8324-8 (1994).
Read more (PubMed: 8078881) »