Overview

  • Product nameAnti-Gelsolin antibody
    See all Gelsolin primary antibodies
  • Description
    Goat polyclonal to Gelsolin
  • SpecificityThis antibody is expected to recognize both reported isoforms (NP_000168.1 and NP_937895.1).
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide:

    C-PRLKDKKMDAHP

    , corresponding to internal sequence amino acids 655-666 of Human Gelsolin

  • Positive control
    • Human Spleen lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab53560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 86 kDa).

    Peptide ELISA: antibody detection limit dilution 1:128,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCalcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
    • Tissue specificityPhagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
    • Involvement in diseaseDefects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
    • Sequence similaritiesBelongs to the villin/gelsolin family.
      Contains 6 gelsolin-like repeats.
    • Post-translational
      modifications
      Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.
    • Cellular localizationCytoplasm > cytoskeleton and Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • Actin depolymerizing factor antibody
      • Actin-depolymerizing factor antibody
      • ADF antibody
      • AGEL antibody
      • Brevin antibody
      • DKFZp313L0718 antibody
      • GELS_HUMAN antibody
      • Gelsolin antibody
      • Gsn antibody
      see all

    Anti-Gelsolin antibody images

    References for Anti-Gelsolin antibody (ab53560)

    ab53560 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab53560.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"