• Product nameAnti-Gelsolin antibody
    See all Gelsolin primary antibodies
  • Description
    Rabbit polyclonal to Gelsolin
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region of Human GSN

  • Positive control
    • MCF cell lysate


Associated products


Our Abpromise guarantee covers the use of ab76418 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 86 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 5 µg/ml.


  • FunctionCalcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
  • Tissue specificityPhagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
  • Involvement in diseaseDefects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
  • Sequence similaritiesBelongs to the villin/gelsolin family.
    Contains 6 gelsolin-like repeats.
  • Post-translational
    Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.
  • Cellular localizationCytoplasm > cytoskeleton and Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Actin depolymerizing factor antibody
    • Actin-depolymerizing factor antibody
    • ADF antibody
    • AGEL antibody
    • Brevin antibody
    • DKFZp313L0718 antibody
    • GELS_HUMAN antibody
    • Gelsolin antibody
    • Gsn antibody
    see all

Anti-Gelsolin antibody images

  • ab76418 at 5µg/ml staining Gelsolin in tonsil tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
  • Anti-Gelsolin antibody (ab76418) at 1 µg/ml + MCF7 cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 86 kDa
    Observed band size : 86 kDa

  • Predicted band size : 86 kDa
    Commercial M1 and M2 are cell culture supernatants of human monocyte derived macrophages.

References for Anti-Gelsolin antibody (ab76418)

This product has been referenced in:
  • Bewley MA  et al. Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae. Mol Cell Proteomics 10:M111.008193 (2011). WB ; Human . Read more (PubMed: 21474794) »
  • Haverland N  et al. Immunoreactivity of anti-gelsolin antibodies: implications for biomarker validation. J Transl Med 8:137 (2010). WB ; Human . Read more (PubMed: 21171974) »

See all 2 Publications for this product

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