Anti-Germinal Center Kinase antibody (ab38289)

Overview

  • Product nameAnti-Germinal Center Kinase antibody
    See all Germinal Center Kinase primary antibodies
  • Description
    Rabbit polyclonal to Germinal Center Kinase
  • Tested applicationsSuitable for: WB, IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide (10-30 aa in length) in the region of 302-318 (ELETYDMFPDTIHSRGQ) of human Human Germinal Center Kinase.

  • Positive control
    • Mouse skeletal muscle tissue lysate. human hepatocarcinoma
  • General notes


    This antibody targets the center part of the protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab38289 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Detects a band of approximately 91 kDa (predicted molecular weight: 91 kDa).
IHC-P 1/50 - 1/100.
ELISA 1/1000.

Target

  • FunctionEnhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion.
  • Tissue specificityHighly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined.
  • Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 CNH domain.
    Contains 1 protein kinase domain.
  • Cellular localizationCytoplasm. Basolateral cell membrane. Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • B lymphocyte serine/threonine protein kinase antibody
    • B lymphocyte serine/threonine-protein kinase antibody
    • BL44 antibody
    • GC kinase antibody
    • GCK antibody
    • Germinal center kinase antibody
    • germinal centre kinase (GC kinase) antibody
    • M4K2_HUMAN antibody
    • Map4k2 antibody
    • MAPK/ERK kinase kinase kinase 2 antibody
    • MEK kinase kinase 2 antibody
    • MEKKK 2 antibody
    • Mitogen activated protein kinase kinase kinase kinase 2 antibody
    • Mitogen-activated protein kinase kinase kinase kinase 2 antibody
    • Rab8 interacting protein antibody
    • Rab8 interacting protein, formerly antibody
    • Rab8-interacting protein antibody
    • RAB8IP antibody
    • RAB8IP, formerly antibody
    see all

Anti-Germinal Center Kinase antibody images

  • Anti-Germinal Center Kinase antibody (ab38289) at 1/100 dilution + Mouse skeletal muscle tissue lysate.

    Predicted band size : 91 kDa
    Observed band size : 91 kDa
    Additional bands at : 45 kDa (possible degradation product).
  • 1/50 ab38289 staining human cancer tissue (hepatocarcinoma) by immunohistochemistry - formalin-fixed, paraffin-embedded tissue. The tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

References for Anti-Germinal Center Kinase antibody (ab38289)

ab38289 has not yet been referenced specifically in any publications.

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