Overview

  • Product nameAnti-GERP antibody
    See all GERP primary antibodies
  • Description
    Goat polyclonal to GERP
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity

    Predicted to work with: Mouse, Rat, Dog, Human, Pig
  • Immunogen

    Synthetic peptide: YGQPSTKHYVTS, corresponding to C terminal amino acids 540-551 of Human GERP.

  • General notesPrincipal Names – TRIM8; GERP; RNF27; tripartite motif-containing 8; ring finger protein 27; tripartite motif protein TRIM8; glioblastoma expressed ring finger protein. Official Gene Symbol - TRIM8. GenBank Accession Number – NP_112174. LocusLink ID - 81603 (human); 93679 (mouse). Gene Ontology terms - zinc ion binding; molecular function unknown; biological process unknown; kinesin complex; nucleus; cellular component unknown.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab4302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Can be blocked with Human GERP peptide (ab23022). No signal obtained yet but low background observed in Human Brain and Human Kidney lysates at up to 1µg / ml.
IHC-P Use a concentration of 4 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionProbable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.
  • Tissue specificityWidely expressed.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesBelongs to the TRIM/RBCC family.
    Contains 2 B box-type zinc fingers.
    Contains 1 RING-type zinc finger.
  • DomainThe coiled coil domain is required for homodimerization.
    The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1.
  • Information by UniProt
  • Database links
  • Alternative names
    • AA408830 antibody
    • BB006755 antibody
    • Glioblastoma-expressed RING finger protein antibody
    • Lioblastoma expressed ring finger protein antibody
    • Probable E3 ubiquitin-protein ligase TRIM8 antibody
    • RING finger protein 27 antibody
    • RNF27 antibody
    • RP11-47A8.4 antibody
    • TRIM8 antibody
    • TRIM8_HUMAN antibody
    • Tripartite motif containing 8 antibody
    • Tripartite motif protein TRIM8 antibody
    • Tripartite motif-containing protein 8 antibody
    see all

Anti-GERP antibody images

  • ab4302 (4µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Shows preferential nuclear staining in convoluted tubules.

References for Anti-GERP antibody (ab4302)

ab4302 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"