Overview

  • Product name
    GF 109203X hydrochloride
  • Description
    Potent, cell-permeable, ATP-competitive PKC inhibitor
  • Biological description
    Potent, cell-permeable, ATP-competitive PKC inhibitor (IC50 values for PKC subtypes are 50 (α), 17 (βI), 16 (βII) and 20 nM (γ)). Inhibits PKC over other kinases (IC50 values are 50 nM (MAPKAP), 100 nM (p70 S6 kinase), 2 μM (cAMP-dependent protein kinase) and 0.7 μM (phosphorylase kinase)). Crosses the blood-brain barrier.
  • Purity
    > 99%

Properties

  • Chemical name
    3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride
  • Molecular weight
    448.95
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C25H24N4O2.HCl
  • CAS Number
    176504-36-2
  • PubChem identifier
    6419775
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54.Cl
  • Source

    Synthetic

  • Research areas

Associated products

References

This product has been referenced in:
  • Cheung HH  et al. Inhibition of protein kinase C reduces ischemia-induced tyrosine phosphorylation of the N-methyl-d-aspartate receptor. J Neurochem 86:1441-9 (2003). Read more (PubMed: 12950452) »
  • Alessi DR The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase. FEBS Lett 402:121-3 (1997). Read more (PubMed: 9037179) »
  • Toullec D  et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266:15771-81 (1991). Read more (PubMed: 1874734) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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