Overview

  • Product nameAnti-GFAP antibody [6F2], prediluted
    See all GFAP primary antibodies
  • Description
    Mouse monoclonal [6F2] to GFAP, prediluted
  • SpecificityThe GFAP monoclonal antibody recognizes a 52KDa protein and stains normal glial cells as well as astrocytomas and ependymomas. It does not react with vimentin, neurofilament, cytokeratin, or desmin
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Intermediate filament of bovine spinal cord.

  • Positive control
    • Brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab86144 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: Prediluted and ready to use.

    Not yet tested in other applications.
  • Target

    • FunctionGFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
    • Tissue specificityExpressed in cells lacking fibronectin.
    • Involvement in diseaseDefects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
    • Sequence similaritiesBelongs to the intermediate filament family.
    • Post-translational
      modifications
      Phosphorylated by PKN1.
    • Cellular localizationCytoplasm. Associated with intermediate filaments.
    • Information by UniProt
    • Database links
    • Alternative names
      • wu:fb34h11 antibody
      • ALXDRD antibody
      • cb345 antibody
      • etID36982.3 antibody
      • FLJ42474 antibody
      • FLJ45472 antibody
      • GFAP antibody
      • GFAP_HUMAN antibody
      • gfapl antibody
      • Glial fibrillary acidic protein antibody
      • Intermediate filament protein antibody
      • wu:fk42c12 antibody
      • xx:af506734 antibody
      • zgc:110485 antibody
      see all

    References for Anti-GFAP antibody [6F2], prediluted (ab86144)

    This product has been referenced in:

    See 1 Publication for this product

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