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Product Name 

GFAP antibody [GA-5] - Astrocyte Marker, prediluted

 

See all GFAP antibodies (29)...

Product type 

Primary antibodies

Description 

Mouse monoclonal [GA-5] to GFAP - Astrocyte Marker, prediluted

Immunogen 

GFAP isolated from porcine spinal cord.

Reacts with 
(species key)

Hu, Rat, Chk, Pig

Specificity 

This antibody reacts with human GFAP.
It shows no cross-reaction with other intermediate filaments.
Anti-GFAP stains astrocytes, ependymal cells and corresponding tumors.

Tested applications 
(see key)

IHC-P


Abreviews 

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(see key)


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Application notes 
(see key)

Recommended dilutions
This antibody is ready to use.
For best results use heat mediated antigen retrieval, this can enhance staining if tissues are over-fixed.
Do not use enzymatic mediated antigen retrieval.
We recommend incubating sections with the antibody for 30-60 minutes at room temperature.

Positive control 
(see definition)

Normal brain or astrocytoma

Cellular localization 

Cytoplasmic

Research areas 

Stem Cells >> Neural Stem Cells >> Glial Restricted Lineage >> Astrocyte
Tags & Cell Markers >> Cell Type Markers >> Neuroscience Markers >> Glial
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Intermediate Filaments >> Class II >> GFAP
Neuroscience >> Cell Type Marker >> Glia marker >> Astrocyte marker
Neuroscience >> Cell Adhesion Proteins >> Cytoskeletal Proteins >> Intermediate Filaments

Relevance 

Glial fibrillary acidic protein (GFAP) is a member of the class III intermediate filament protein family. It is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells. In addition many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes.

 

Alternative names GFAP antibody [GA-5] - Astrocyte Marker, prediluted (ab9551)

Database links 

The links below go to external sites and will open in a new browser window

Entrez Gene

    

419969    (Chicken)
2670    (Human)
396562    (Pig)
24387    (Rat)

GeneCard

    

GC17M040338    (Human)

Omim

    

137780    (Human)

SwissProt

    

P14136    (Human)
P47819    (Rat)

Unigene

    

514227    (Human)
91512    (Rat)

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

GA-5

Isotype 

IgG1

Purity 

IgG fraction

Storage buffer 

Preservative: 0.09% Sodium Azide
Constituents: PBS, Carrier protein, pH 7.3

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Storage instructions 

Store at +4°C. Do not freeze.

Notes 

GFAP is Glial Fibrillary Acidic Protein

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this GFAP antibody [GA-5] - Astrocyte Marker, prediluted is on this datasheet. But please do contact us if you would like any reassurance!


 

Search PubMed (MEDLINE) for references to GFAP

 

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