Recombinant
RabMAb

Anti-GGCX antibody [EPR11632] (ab170921)

Overview

  • Product name
    Anti-GGCX antibody [EPR11632]
    See all GGCX primary antibodies
  • Description
    Rabbit monoclonal [EPR11632] to GGCX
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, ICC/IFmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    Recombinant fragment within Human GGCX. The exact sequence is proprietary.
    Database link: P38435

  • Positive control
    • Human placenta, MCF7, 293T and HeLa cell lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.01% Sodium azide
    Constituents: 50% Glycerol, 0.05% BSA
  • Purity
    Tissue culture supernatant
  • Clonality
    Monoclonal
  • Clone number
    EPR11632
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab170921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 88 kDa.
ICC/IF 1/100 - 1/250.
  • Application notes
    Is unsuitable for Flow Cyt,IHC-P or IP.
  • Target

    • Function
      Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
    • Involvement in disease
      Defects in GGCX are a cause of combined deficiency of vitamin K-dependent clotting factors type 1 (VKCFD1) [MIM:277450]; also known as multiple coagulation factor deficiency III (MCFD3). VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K.
      Defects in GGCX are the cause of pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency (PXEL-MCFD) [MIM:610842]. This syndrome is characterized by hyperlaxity of the skin involving the entire body. Important phenotypic differences with classical PXE include much more severe skin laxity with spreading toward the trunk and limbs with thick, leathery skin folds rather than confinement to flexural areas, and no decrease in visual acuity. Moreover, detailed electron microscopic analyzes revealed that alterations of elastic fibers as well as their mineralization are slightly different from those in classic PXE.
    • Sequence similarities
      Belongs to the vitamin K-dependent gamma-carboxylase family.
    • Cellular localization
      Endoplasmic reticulum membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ26629 antibody
      • Gamma glutamyl carboxylase antibody
      • Gamma-glutamyl carboxylase antibody
      • GC antibody
      • GGCX antibody
      • Peptidyl glutamate 4 carboxylase antibody
      • Peptidyl-glutamate 4-carboxylase antibody
      • Vitamin K dependent gamma carboxylase antibody
      • Vitamin K gamma glutamyl carboxylase antibody
      • Vitamin K-dependent gamma-carboxylase antibody
      • VKCFD 1 antibody
      • VKCFD1 antibody
      • VKGC_HUMAN antibody
      see all

    Images

    • Immunofluorescent staining of HeLa cells labeling GGCX with ab170921 at 1/100 (green). DAPI nuclear staining (blue).

    • All lanes : Anti-GGCX antibody [EPR11632] (ab170921) at 1/1000 dilution

      Lane 1 : Human placenta lysate
      Lane 2 : MCF7 cell lysate
      Lane 3 : 293T cell lysate
      Lane 4 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution

      Developed using the ECL technique.

      Predicted band size: 88 kDa

    References

    ab170921 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab170921.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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