Anti-Ghrelin antibody [121] (Biotin) (ab121067)

Overview

  • Product nameAnti-Ghrelin antibody [121] (Biotin)
    See all Ghrelin primary antibodies
  • Description
    Mouse monoclonal [121] to Ghrelin (Biotin)
  • ConjugationBiotin
  • Tested applicationsSuitable for: Sandwich ELISAmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse, Goat, Cat, Dog, Rhesus monkey
  • Immunogen

    Synthetic peptide corresponding to Human Ghrelin aa 37-51. Ghrelin-28 peptide.
    Sequence:

    QRKESKKPPAKLQPR


    Database link: Q9UBU3

Properties

Applications

Our Abpromise guarantee covers the use of ab121067 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA 1/4000. ab121066 should be used as the capture antibody and ab121067 and the detection antibody

Target

  • FunctionGhrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
    Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
  • Tissue specificityHighest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
  • Sequence similaritiesBelongs to the motilin family.
  • Post-translational
    modifications
    O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.
    Amidation of Leu-98 is essential for obestatin activity.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Appetite regulating hormone antibody
    • Ghrelin 27 antibody
    • Ghrelin 28 antibody
    • Ghrelin and obestatin prepropeptide antibody
    • Ghrelin antibody
    • Ghrelin/obestatin prepropeptide antibody
    • ghrl antibody
    • GHRL_HUMAN antibody
    • Growth hormone releasing peptide antibody
    • Growth hormone secretagogue antibody
    • Growth hormone-releasing peptide antibody
    • M46 protein antibody
    • Motilin related peptide antibody
    • Motilin-related peptide antibody
    • MTLRP antibody
    • Obestatin antibody
    • Protein M46 antibody
    see all

References for Anti-Ghrelin antibody [121] (Biotin) (ab121067)

ab121067 has not yet been referenced specifically in any publications.

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