Overview

  • Product nameAnti-Ghrelin antibody [45]
    See all Ghrelin primary antibodies
  • Description
    Mouse monoclonal [45] to Ghrelin
  • Specificityab112477 binds Human ghrelin and Human des-acyl ghrelin, cross-reacting ~5% with rat ghrelin (determined by sandwich ELISA).
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic Human Ser3-octanoyl ghrelin-28

  • EpitopeNot determined. Probably includes residues 11 or 12 to account for the lower cross-reactivity with rat ghrelin.

Properties

Target

  • FunctionGhrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
    Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
  • Tissue specificityHighest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
  • Sequence similaritiesBelongs to the motilin family.
  • Post-translational
    modifications
    O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.
    Amidation of Leu-98 is essential for obestatin activity.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Appetite regulating hormone antibody
    • Ghrelin 27 antibody
    • Ghrelin 28 antibody
    • Ghrelin and obestatin prepropeptide antibody
    • Ghrelin antibody
    • Ghrelin/obestatin prepropeptide antibody
    • ghrl antibody
    • GHRL_HUMAN antibody
    • Growth hormone releasing peptide antibody
    • Growth hormone secretagogue antibody
    • Growth hormone-releasing peptide antibody
    • M46 protein antibody
    • Motilin related peptide antibody
    • Motilin-related peptide antibody
    • MTLRP antibody
    • Obestatin antibody
    • Protein M46 antibody
    see all

References for Anti-Ghrelin antibody [45] (ab112477)

This product has been referenced in:

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab112477.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"