Anti-Ghrelin Receptor/GHS-R antibody (ab85104)
Key features and details
- Rabbit polyclonal to Ghrelin Receptor/GHS-R
- Suitable for: WB, IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-Ghrelin Receptor/GHS-R antibody
See all Ghrelin Receptor/GHS-R primary antibodies -
Description
Rabbit polyclonal to Ghrelin Receptor/GHS-R -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Rat, Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 2% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab85104 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (2) |
1/200 - 1/1000. Detects a band of approximately 40 kDa.
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IHC-P |
1/100 - 1/500.
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Notes |
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WB
1/200 - 1/1000. Detects a band of approximately 40 kDa. |
IHC-P
1/100 - 1/500. |
Target
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Function
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). -
Tissue specificity
Pituitary and hypothalamus. -
Involvement in disease
Defects in GHSR may be a cause of idiopathic short stature autosomal (ISSA) [MIM:604271]. Short stature is defined by a subnormal rate of growth. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 2693 Human
- Entrez Gene: 208188 Mouse
- Entrez Gene: 84022 Rat
- Omim: 601898 Human
- SwissProt: Q92847 Human
- SwissProt: Q99P50 Mouse
- SwissProt: O08725 Rat
- Unigene: 130212 Human
see all -
Alternative names
- GH releasing peptide receptor antibody
- GH-releasing peptide receptor antibody
- Ghrelin receptor antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (12)
ab85104 has been referenced in 12 publications.
- Nogueira AVB et al. Effect of Bacterial Infection on Ghrelin Receptor Regulation in Periodontal Cells and Tissues. Int J Mol Sci 23:N/A (2022). PubMed: 35328456
- Jeong H et al. Ghrelin Represses Thymic Stromal Lymphopoietin Gene Expression through Activation of Glucocorticoid Receptor and Protein Kinase C Delta in Inflamed Skin Keratinocytes. Int J Mol Sci 23:N/A (2022). PubMed: 35409338
- Chu G et al. Involvement of POMC neurons in LEAP2 regulation of food intake and body weight. Front Endocrinol (Lausanne) 13:932761 (2022). PubMed: 36387867
- Lin Y et al. Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway. Cell Commun Signal 17:8 (2019). PubMed: 30683114
- Rasineni K et al. Chronic alcohol exposure alters circulating insulin and ghrelin levels: role of ghrelin in hepatic steatosis. Am J Physiol Gastrointest Liver Physiol 316:G453-G461 (2019). PubMed: 30702902