Overview

  • Product nameAnti-Girdin antibody
    See all Girdin primary antibodies
  • Description
    Rabbit polyclonal to Girdin
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Orangutan, Elephant
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 425-475 of Human Girdin (NP_001129069.1)

  • Positive control
    • HeLa whole cell lysates.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab113282 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionPlays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
    • Tissue specificityExpressed ubiquitously.
    • Sequence similaritiesBelongs to the CCDC88 family.
    • Post-translational
      modifications
      Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration.
    • Cellular localizationMembrane. Cell membrane. Cytoplasm > cytosol. Cytoplasmic vesicle. Cell projection > lamellipodium. Localizes to the cell membrane through interaction with phosphoinositides.
    • Information by UniProt
    • Database links
    • Alternative names
      • AKT iphosphorylation enhancer antibody
      • Akt phosphorylation enhancer antibody
      • APE antibody
      • Ccdc88a antibody
      • Coiled coil domain containing 88A antibody
      • Coiled coil domain containing protein 88A antibody
      • Coiled-coil domain-containing protein 88A antibody
      • FLJ10392 antibody
      • G alpha interacting vesicle associated protein antibody
      • G alpha-interacting vesicle-associated protein antibody
      • Galpha interacting vesicle associated protein antibody
      • Girders of actin filament antibody
      • Girdin antibody
      • GIV antibody
      • GRDN antibody
      • GRDN_HUMAN antibody
      • HkRP1 antibody
      • Hook related protein 1 antibody
      • Hook-related protein 1 antibody
      • KIAA1212 antibody
      see all

    Anti-Girdin antibody images

    • Detection of Girdin by Western Blot of Immunprecipitate.
      An antibody to Girdin at 1µg/ml staining Girdin in HeLa whole cell lysate immunoprecipitated using ab113282 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 30 seconds.

    References for Anti-Girdin antibody (ab113282)

    ab113282 has not yet been referenced specifically in any publications.

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