Overview

  • Product name
  • Description
    Rabbit polyclonal to GIRK2
  • Specificity
    Reacts specifically with human 48 kDa protein.
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the C terminal domain of human GIRK2.

Properties

Applications

Our Abpromise guarantee covers the use of ab66502 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/5000. Predicted molecular weight: 47 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • Function
    This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
  • Tissue specificity
    Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas.
  • Involvement in disease
    Keppen-Lubinsky syndrome
  • Sequence similarities
    Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • inwardly rectifying subfamily J member 6 antibody
    • BIR1 antibody
    • G protein activated inward rectifier potassium channel 2 antibody
    • G protein-activated inward rectifier potassium channel 2 antibody
    • GIRK-2 antibody
    • GIRK2 antibody
    • hiGIRK2 antibody
    • Inward rectifier K(+) channel Kir3.2 antibody
    • Inward rectifier potassium channel KIR3.2 antibody
    • KATP-2 antibody
    • KATP2 antibody
    • KCNJ6 antibody
    • KCNJ6_HUMAN antibody
    • Kcnj7 antibody
    • KIR3.2 antibody
    • KPLBS antibody
    • Potassium channel antibody
    • Potassium channel inwardly rectifying subfamily J member 6 antibody
    • Potassium inwardly rectifying channel subfamily J member 6 antibody
    • Potassium voltage gated channel subfamily J member 6 antibody
    see all

References

This product has been referenced in:
  • Huo Q  et al. Prefrontal Cortical GABAergic Dysfunction Contributes to Aberrant UP-State Duration in APP Knockout Mice. Cereb Cortex N/A:N/A (2016). Read more (PubMed: 27552836) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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