Overview

  • Product nameAnti-GJA3 antibody
    See all GJA3 primary antibodies
  • Description
    Rabbit polyclonal to GJA3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Horse, Pig, Saccharomyces cerevisiae, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within the N terminal amino acids 72-121 (ISHIRFWALQ IIFVSTPTLI YLGHVLHIVR MEEKKKEREE EEQLKRESPS) of human GJA3 (NP_068773).

  • Positive control
    • 721_B cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab85892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 47 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionOne gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • Involvement in diseaseDefects in GJA3 are the cause of cataract zonular pulverulent cataract type 3 (CZP3) [MIM:601885]. A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.
  • Sequence similaritiesBelongs to the connexin family. Alpha-type (group II) subfamily.
  • Cellular localizationCell membrane. Cell junction > gap junction.
  • Information by UniProt
  • Database links
  • Alternative names
    • CAE3 antibody
    • Connexin 46 antibody
    • Connexin-46 antibody
    • Connexin46 antibody
    • Cx46 antibody
    • CXA3_HUMAN antibody
    • CZP3 antibody
    • Gap junction alpha 3 protein antibody
    • Gap junction alpha-3 protein antibody
    • Gap junction protein, alpha 3, 46kD (connexin 46) antibody
    • Gap junction protein, alpha 3, 46kDa (connexin 46) antibody
    • Gap junction protein, alpha 3, 46kDa antibody
    • Gja3 antibody
    see all

Anti-GJA3 antibody images

  • Anti-GJA3 antibody (ab85892) at 1 µg/ml + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 47 kDa
    Observed band size : 47 kDa
    Additional bands at : >90 kDa. We are unsure as to the identity of these extra bands.

References for Anti-GJA3 antibody (ab85892)

ab85892 has not yet been referenced specifically in any publications.

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