• Product nameAnti-GJB2 antibody
    See all GJB2 primary antibodies
  • Description
    Rabbit polyclonal to GJB2
  • Tested applicationsSuitable for: IHC-P, ELISA, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide (10-30 aa in length) at the C-term of last 50 aa of human GJB2 conjugated to KLH

  • Positive control
    • mouse brain tissue lysate. human hepatocarcinoma.



Our Abpromise guarantee covers the use of ab38584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100.
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 24 kDa (predicted molecular weight: 26 kDa).


  • FunctionOne gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • Involvement in diseaseDefects in GJB2 are the cause of deafness autosomal recessive type 1A (DFNB1A) [MIM:220290]. DFNB1A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Defects in GJB2 are the cause of deafness autosomal dominant type 3A (DFNA3A) [MIM:601544].
    Defects in GJB2 are a cause of Vohwinkel syndrome (VS) [MIM:124500]. VS is an autosomal dominant disease characterized by hyperkeratosis, constriction on finger and toes and congenital deafness.
    Defects in GJB2 are a cause of palmoplantar keratoderma with deafness (PPKDFN) [MIM:148350]. PPKDFN is an autosomal dominant disorder characterized by the association of palmoplantar hyperkeratosis with progressive, bilateral, high-frequency, sensorineural deafness.
    Defects in GJB2 are a cause of keratitis-ichthyosis-deafness syndrome (KID syndrome) [MIM:148210]; an autosomal dominant form of ectodermal dysplasia. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. KID syndrome is characterized by the association of hyperkeratotic skin lesions with vascularizing keratitis and profound sensorineural hearing loss. Clinical features include deafness, ichthyosis, photobia, absent or decreased eyebrows, sparse or absent scalp hair, decreased sweating and dysplastic finger and toenails.
    Defects in GJB2 are the cause of Bart-Pumphrey syndrome (BPS) [MIM:149200]. BPS is an autosomal dominant disorder characterized by sensorineural hearing loss, palmoplantar keratoderma, knuckle pads, and leukonychia, It shows considerable phenotypic variability.
    Defects in GJB2 are the cause of ichthyosis hystrix-like with deafness syndrome (HID syndrome) [MIM:602540]. HID syndrome is an autosomal-dominant inherited keratinizing disorder characterized by sensorineural deafness and spiky hyperkeratosis affecting the entire skin. HID syndrome is considered to differ from the similar KID syndrome in the extent and time of occurrence of skin symptoms and the severity of the associated keratitis.
  • Sequence similaritiesBelongs to the connexin family. Beta-type (group I) subfamily.
  • Cellular localizationCell membrane. Cell junction > gap junction.
  • Information by UniProt
  • Database links
  • Alternative names
    • connexin 26 antibody
    • Connexin-26 antibody
    • Cx26 antibody
    • CXB2_HUMAN antibody
    • DFNA3 antibody
    • DFNB1 antibody
    • Gap junction beta-2 protein antibody
    • GJB2 antibody
    • HID antibody
    • KID antibody
    • NSRD1 antibody
    • PPK antibody
    see all

Anti-GJB2 antibody images

  • Immunohistochemical analysis of GJB2 expression in formalin-fixed and paraffin-embedded human hepatocarcinoma tissue using 1/50 ab38584.
  • Anti-GJB2 antibody (ab38584) at 1/100 dilution + Mouse brain tissue lysate

    Predicted band size : 26 kDa
    Observed band size : 26 kDa

References for Anti-GJB2 antibody (ab38584)

This product has been referenced in:
  • Lutz SE  et al. Deletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolation. J Neurosci 29:7743-52 (2009). Read more (PubMed: 19535586) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab38584.
Please use the links above to contact us or submit feedback about this product.