Overview

  • Product name
  • Description
    Rabbit polyclonal to GJB3
  • Specificity
    This antibody reacts with GJB3.
  • Tested applications
    Suitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A KLH conjugated synthetic peptide selected from the C terminal region of human GJB3.

  • Positive control
    • Human hepatocarcinoma tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab59925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • Function
    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • Involvement in disease
    Defects in GJB3 are a cause of erythrokeratodermia variabilis (EKV) [MIM:133200]. EKV is a genodermatosis characterized by the appearance of two independent skin lesions: transient figurate erythematous patches and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases.
    Defects in GJB3 are the cause of deafness autosomal dominant type 2B (DFNA2B) [MIM:612644]. DFNA2 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • Sequence similarities
    Belongs to the connexin family. Beta-type (group I) subfamily.
  • Cellular localization
    Cell membrane. Cell junction > gap junction.
  • Information by UniProt
  • Database links
  • Alternative names
    • Connexin 31 antibody
    • Connexin-31 antibody
    • Connexin31 antibody
    • CX 31 antibody
    • Cx31 antibody
    • CXB3_HUMAN antibody
    • DFNA 2 antibody
    • DFNA2 antibody
    • DFNA2B antibody
    • EKV antibody
    • FLJ22486 antibody
    • Gap junction beta 3 protein antibody
    • Gap junction beta-3 protein antibody
    • Gap junction protein beta 3 31kDa antibody
    • Gap junction protein beta 3 antibody
    • GJB 3 antibody
    • Gjb3 antibody
    • MGC102938 antibody
    see all

Anti-GJB3 antibody images

  • Formalin fixed and paraffin embedded human hepatocarcinoma tissue reacted with ab59925 at 1/50 dilution, which was peroxidase conjugated to the secondary antibody, followed by AEC staining.

References for Anti-GJB3 antibody (ab59925)

ab59925 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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