Recombinant
RabMAb

Anti-GJB3 antibody [EPR6977(2)] (ab156582)

Overview

  • Product name
    Anti-GJB3 antibody [EPR6977(2)]
    See all GJB3 primary antibodies
  • Description
    Rabbit monoclonal [EPR6977(2)] to GJB3
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human GJB3.

  • Positive control
    • Human testis, HeLa and SH-SY5Y lysates
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab156582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 31 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function
      One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
    • Involvement in disease
      Defects in GJB3 are a cause of erythrokeratodermia variabilis (EKV) [MIM:133200]. EKV is a genodermatosis characterized by the appearance of two independent skin lesions: transient figurate erythematous patches and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases.
      Defects in GJB3 are the cause of deafness autosomal dominant type 2B (DFNA2B) [MIM:612644]. DFNA2 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    • Sequence similarities
      Belongs to the connexin family. Beta-type (group I) subfamily.
    • Cellular localization
      Cell membrane. Cell junction > gap junction.
    • Information by UniProt
    • Database links
    • Alternative names
      • Connexin 31 antibody
      • Connexin-31 antibody
      • Connexin31 antibody
      • CX 31 antibody
      • Cx31 antibody
      • CXB3_HUMAN antibody
      • DFNA 2 antibody
      • DFNA2 antibody
      • DFNA2B antibody
      • EKV antibody
      • FLJ22486 antibody
      • Gap junction beta 3 protein antibody
      • Gap junction beta-3 protein antibody
      • Gap junction protein beta 3 31kDa antibody
      • Gap junction protein beta 3 antibody
      • GJB 3 antibody
      • Gjb3 antibody
      • MGC102938 antibody
      see all

    Images

    • All lanes : Anti-GJB3 antibody [EPR6977(2)] (ab156582) at 1/1000 dilution

      Lane 1 : Human testis lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : SH-SY5Y cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 31 kDa

    References

    ab156582 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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