• Product name
  • Description
    Rabbit polyclonal to GJC2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Cat
  • Immunogen

    Synthetic peptide corresponding to a region within the internal sequence amino acids 389-438 (PASRTGSATSAGTVGEQGRPGTHERPGAKPRAGSEKGSASSRDGKTTVW I) of Human GJC2, NP_065168

  • Positive control
    • MCF7 cell lysate



Our Abpromise guarantee covers the use of ab86215 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 47 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function
    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.
  • Tissue specificity
    Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles.
  • Involvement in disease
    Defects in GJC2 are the cause of leukodystrophy hypomyelinating type 2 (HLD2) [MIM:608804]; also known as Pelizaeus-Merzbacher-like disease autosomal recessive type 1. HLD2 is an autosomal recessive hypomyelinating leukodystrophy characterized by nystagmus, impaired motor development, ataxia, choreoathetotic movements, dysarthria and progressive spasticity.
    Defects in GJC2 are the cause of spastic paraplegia autosomal recessive type 44 (SPG44) [MIM:613206]. A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
    Defects in GJC2 are the cause of lymphedema hereditary type 1C (LMPH1C) [MIM:613480]. LMPH1C is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.
  • Sequence similarities
    Belongs to the connexin family. Gamma-type subfamily.
  • Cellular localization
    Cell membrane. Cell junction > gap junction.
  • Information by UniProt
  • Database links
  • Alternative names
    • B230382L12Rik antibody
    • Connexin 46.6 antibody
    • Connexin 47 antibody
    • Connexin-46.6 antibody
    • Connexin-47 antibody
    • Connexin46.6 antibody
    • Connexin47 antibody
    • CX 46.6 antibody
    • Cx 47 antibody
    • Cx46.6 antibody
    • Cx47 antibody
    • CXG2_HUMAN antibody
    • Gap junction alpha 12 protein antibody
    • Gap junction alpha-12 protein antibody
    • Gap junction gamma 2 protein antibody
    • Gap junction gamma-2 protein antibody
    • Gap junction protein alpha 12 47kDa antibody
    • Gap junction protein gamma 2 47kDa antibody
    • GAP JUNCTION PROTEIN, 47-KD antibody
    • gap junction protein, gamma 12, 47kDa antibody
    • gap junction protein, gamma 2, 47kDa antibody
    • GJA 12 antibody
    • GJA12 antibody
    • GJC 2 antibody
    • Gjc2 antibody
    • HLD 2 antibody
    • HLD2 antibody
    • LMPH1C antibody
    • MGC105119 antibody
    • MGC130506 antibody
    • OTTHUMP00000037763 antibody
    • PMLDAR antibody
    • SPG44 antibody
    see all

Anti-GJC2 antibody images

  • Anti-GJC2 antibody (ab86215) at 1 µg/ml + MCF7 cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 47 kDa
    Observed band size : 47 kDa
    Gel concentration: 12%

  • Predicted band size : 47 kDa
    Western Blot using ab86215 at 1.0ug/ml. Sample type: Human 293T cell Lysate

References for Anti-GJC2 antibody (ab86215)

ab86215 has not yet been referenced specifically in any publications.

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I am sorry to confirm that as far as we are aware, ab86215 has never been tested in IHC-Fr. All tested applications covered by the 6 month guarantee are specified on our datasheets, and these are updated as soon a...

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