Overview

  • Product nameAnti-GLDC antibody
    See all GLDC primary antibodies
  • Description
    Rabbit polyclonal to GLDC
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant protein fragment corresponding to a region within amino acids 492 and 693 of Human GLDC (NP_000161).

  • Positive control
    • HepG2 cells and lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab97625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 113 kDa.
ICC/IF 1/100 - 1/200.

Target

  • FunctionThe glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
  • Involvement in diseaseDefects in GLDC are a cause of non-ketotic hyperglycinemia (NKH) [MIM:605899]; also known as glycine encephalopathy (GCE). NKH is an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.
  • Sequence similaritiesBelongs to the gcvP family.
  • Cellular localizationMitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • GCE antibody
    • GCSP antibody
    • GCSP_HUMAN antibody
    • GLDC antibody
    • Glycine cleavage system P protein antibody
    • glycine cleavage system protein P antibody
    • Glycine decarboxylase antibody
    • glycine decarboxylase P protein antibody
    • Glycine dehydrogenase (decarboxylating) mitochondrial antibody
    • Glycine dehydrogenase [decarboxylating], mitochondrial antibody
    • Gycine dehydrogenase (decarboxylating) antibody
    • HYGN1 antibody
    • MGC138198 antibody
    • MGC138200 antibody
    • NKH antibody
    see all

Anti-GLDC antibody images

  • All lanes : Anti-GLDC antibody (ab97625) at 1/500 dilution

    Lane 1 : HeLa whole cell lysate
    Lane 2 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 113 kDa

    5% SDS-PAGE

  • ab97625, at a 1/200 dilution, staining GLDC in methanol fixed HeLa cells by Immunofluorescence analysis. Lower image was co-stained with Hoechst 33342.

References for Anti-GLDC antibody (ab97625)

This product has been referenced in:
  • Kim SK  et al. Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes. PLoS One 9:e101004 (2014). WB ; Human . Read more (PubMed: 24979213) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"