Overview

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab28675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 50 kDa (predicted molecular weight: 48 kDa).

Target

  • RelevanceGliomedin is a member of the collagen superfamily, it is a glial ligand for neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier. Gliomedin provides a glial cue for the formation of peripheral nodes of Ranvier. Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, where it aligns with the forming nodes of ranvier. Eliminating the expression of gliomedin or the addition of a soluble extracellular domain of neurofascin to myelinating cultures abolishes node formation. Gliomedin is expressed in the PNS nodes of ranvier, but not in the CNS nodes of ranvier. Gliomedin also displays high expression in murine and human hepatocellular carcinomas (HCC). Its restricted expression in normal tissues and unique early upregulation during tumor development make it an excellent candidate as a new clinical marker of HCC.
  • Cellular localizationCell Membrane and Cytoplasmic
  • Database links
  • Alternative names
    • CANCER RELATED GENE LIVER 2 antibody
    • Cancer related gene-Liver 2 antibody
    • CLOM antibody
    • collomin antibody
    • Colm (gene name) antibody
    • COLM antibody
    • Colmedin antibody
    • CRG L2 antibody
    • CRGL2 antibody
    • FLJ23917 antibody
    • Gldn (gene name) antibody
    • UNC 112 antibody
    see all

Anti-Gliomedin antibody images

References for Anti-Gliomedin antibody (ab28675)

ab28675 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"