Overview

  • Product nameAnti-GLRB antibody
    See all GLRB primary antibodies
  • Description
    Rabbit polyclonal to GLRB
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 102-132 of Human GLRB (NP_001159532.1, NP_000815.1).

  • Positive control
    • Mouse cerebellum tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab123886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 56 kDa.

Target

  • RelevanceGLRB (Glycine receptor beta) is a neurotransmitter-gated ion channel concentrated within the spinal cord and brainstem. Expression is also observed in several upper brain regions including the cortex, cerebellum, hippocampus and amygdala. Binding of glycine to GLRB increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing), controlling spinal reflexes and locomotor behavior.
  • Cellular localizationPlasma membrane; multi-pass membrane protein.
  • Database links
  • Alternative names
    • Glycine receptor 58 kDa subunit antibody
    • Glycine receptor beta antibody
    • Glycine receptor subunit beta antibody
    • Glycine receptor, beta subunit antibody
    • OTTHUMP00000220896 antibody
    • OTTHUMP00000220897 antibody
    see all

Anti-GLRB antibody images

  • Anti-GLRB antibody (ab123886) at 1/100 dilution + Mouse cerebellum tissue lysate at 35 µg

    Predicted band size : 56 kDa

References for Anti-GLRB antibody (ab123886)

This product has been referenced in:
  • James VM  et al. Novel missense mutations in the glycine receptor ß subunit gene (GLRB) in startle disease. Neurobiol Dis 52:137-49 (2013). WB ; Human . Read more (PubMed: 23238346) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"