Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab169954 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-GLS2 antibody (ab113509)

  • Form
    Liquid

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • breast cell glutaminase
    • GA
    • GLS
    • Gls2
    • GLSL_HUMAN
    • glutaminase 2
    • glutaminase 2 (liver mitochondrial)
    • glutaminase GA
    • glutaminase I
    • Glutaminase liver isoform
    • Glutaminase liver isoform, mitochondrial
    • hLGA
    • L glutaminase
    • L glutamine amidohydrolase
    • L-glutaminase
    • L-glutamine amidohydrolase
    • LGA
    • mitochondrial
    • phosphate activated glutaminase
    • phosphate-dependent glutaminase
    see all
  • Function
    Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
  • Tissue specificity
    Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas.
  • Sequence similarities
    Belongs to the glutaminase family.
    Contains 2 ANK repeats.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt

References

ab169954 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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