Anti-Glucocorticoid Receptor antibody [8E9] (ab11379)

Overview

  • Product nameAnti-Glucocorticoid Receptor antibody [8E9]
    See all Glucocorticoid Receptor primary antibodies
  • Description
    Mouse monoclonal [8E9] to Glucocorticoid Receptor
  • SpecificityAb11379 recognises the human glucocorticoid receptor.
  • Tested applicationsSuitable for: WB, ELISAmore details
    Unsuitable for: IHC-Fr,IHC-P or IHC-R
  • Species reactivity
    Reacts with: Human
  • Immunogen

    26 amino acid peptide corresponding to residues 150-176 of human GCR linked to thyroglobulin (human).

  • EpitopeClone 8E9 binds to an epitope between amino acids 167-176.
  • General notesThis product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Properties

Applications

Our Abpromise guarantee covers the use of ab11379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 87 kDa.
ELISA 1/1000.
  • Application notesIs unsuitable for IHC-Fr,IHC-P or IHC-R.
  • Target

    • FunctionReceptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.
    • Tissue specificityWidely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
    • Involvement in diseaseDefects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.
    • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR3 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
    • Post-translational
      modifications
      Increased proteasome-mediated degradation in response to glucocorticoids.
      Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203-phosphorylated form is mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Transcriptional activity correlates with the amount of phosphorylation at Ser-211.
      Sumoylated; this reduces transcription transactivation.
      Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
    • Cellular localizationCytoplasm. Nucleus. Cytoplasmic in the absence of ligand, nuclear after ligand-binding and Nucleus. Localized largely in the nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • GCCR antibody
      • GCR antibody
      • GCR_HUMAN antibody
      • GCRST antibody
      • glucocorticoid nuclear receptor variant 1 antibody
      • Glucocorticoid receptor antibody
      • GR antibody
      • GRL antibody
      • Grl1 antibody
      • nr3c1 antibody
      • Nuclear receptor subfamily 3 group C member 1 antibody
      • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) antibody
      see all

    References for Anti-Glucocorticoid Receptor antibody [8E9] (ab11379)

    ab11379 has not yet been referenced specifically in any publications.

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