Anti-Glucocorticoid Receptor beta antibody (ab85622)


  • Product nameAnti-Glucocorticoid Receptor beta antibody
    See all Glucocorticoid Receptor beta primary antibodies
  • Description
    Rabbit polyclonal to Glucocorticoid Receptor beta
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived within aa720 - aa750 of Human Glucocorticoid Receptor beta



Our Abpromise guarantee covers the use of ab85622 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Detects a band of approximately 86 kDa (predicted molecular weight: 86 kDa).
ELISA 1/1000.


  • FunctionReceptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.
  • Tissue specificityWidely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
  • Involvement in diseaseDefects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Post-translational
    Increased proteasome-mediated degradation in response to glucocorticoids.
    Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203-phosphorylated form is mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Transcriptional activity correlates with the amount of phosphorylation at Ser-211.
    Sumoylated; this reduces transcription transactivation.
    Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
  • Cellular localizationCytoplasm. Nucleus. Cytoplasmic in the absence of ligand, nuclear after ligand-binding and Nucleus. Localized largely in the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • GCCR antibody
    • GCR antibody
    • GCR_HUMAN antibody
    • glucocorticoid nuclear receptor variant 1 antibody
    • Glucocorticoid receptor antibody
    • Glucocorticoid receptor beta isoform antibody
    • GR antibody
    • GRL antibody
    • nr3c1 antibody
    • Nuclear receptor subfamily 3 group C member 1 antibody
    see all

Anti-Glucocorticoid Receptor beta antibody images

  • Anti-Glucocorticoid Receptor beta antibody (ab85622) at 1/500 dilution + 35µg of A549 whole cell lysate

    Goat anti-rabbit IgG conjugate dto HRP

    Predicted band size : 86 kDa
    Additional bands at : 125 kDa,79 kDa. We are unsure as to the identity of these extra bands.

References for Anti-Glucocorticoid Receptor beta antibody (ab85622)

ab85622 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab85622.
Please use the links above to contact us or submit feedback about this product.