Anti-glucose-6-phosphatase, catalytic subunit antibody (ab93857)


  • Product name
    Anti-glucose-6-phosphatase, catalytic subunit antibody
    See all glucose-6-phosphatase, catalytic subunit primary antibodies
  • Description
    Rabbit polyclonal to glucose-6-phosphatase, catalytic subunit
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cat, Macaque monkey
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 300 to the C-terminus of Human glucose-6-phosphatase, catalytic subunit.

  • Positive control
    • This antibody gave a positive signal in both HepG2 and HEK293 human whole cell lysates.



Our Abpromise guarantee covers the use of ab93857 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 40 kDa).


  • Function
    Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
  • Pathway
    Carbohydrate biosynthesis; gluconeogenesis.
  • Involvement in disease
    Defects in G6PC are the cause of glycogen storage disease type 1A (GSD1A) [MIM:232200]. A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia.
  • Sequence similarities
    Belongs to the glucose-6-phosphatase family.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AW107337 antibody
    • G-6-Pase antibody
    • G6Pase antibody
    • G6Pase-alpha antibody
    • g6pc antibody
    • G6PC_HUMAN antibody
    • G6PT antibody
    • Glucose-6-phosphatase alpha antibody
    • Glucose-6-phosphatase antibody
    • GSD1 antibody
    • GSD1a antibody
    • MGC163350 antibody
    • MGC93613 antibody
    • RP23-281C18.19 antibody
    see all


  • All lanes : Anti-glucose-6-phosphatase, catalytic subunit antibody (ab93857) at 1 µg/ml

    Lane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate
    Lane 2 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate
    Lane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate with immunising peptide at 1 µg/ml
    Lane 4 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate with immunising peptide at 1 µg/ml

    Lysates/proteins at 10 µg per lane.

    All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size: 40 kDa
    Observed band size: 37 kDa (why is the actual band size different from the predicted?)
    Additional bands at: 17 kDa, 22 kDa, 44 kDa. We are unsure as to the identity of these extra bands.

    Exposure time: 1 minute


ab93857 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you so much for keeping me updated, and I am so happy to hear that the replacement G6PC antibody worked so well! Please let me know if there is anything else that we can do for you, and have a great day!

Thank you for your call today and for letting us know about the trouble with ab83690. It was a pleasure speaking to you.

As we discussed, I'm sending a vial of ab93857 free of charge on the order ***. This is in stock and should arrive tomorr...

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