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Function
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
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Tissue specificity
Isoform Long is found in lymphoblasts, granulocytes and sperm.
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Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
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Involvement in disease
Anemia, non-spherocytic hemolytic, due to G6PD deficiency
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Sequence similarities
Belongs to the glucose-6-phosphate dehydrogenase family.
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Post-translational
modifications
Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity.
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Information by UniProt
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Alternative names
- G6PD antibody
- G6PD_HUMAN antibody
- G6PD1 antibody
- G6pdx antibody
- Glucose 6 phosphate 1 dehydrogenase antibody
- Glucose 6 phosphate dehydrogenase antibody
- Glucose 6 phosphate dehydrogenase, G6PD antibody
- Glucose-6-phosphate 1-dehydrogenase antibody
- MET19 antibody
- POS10 antibody
- Zwf1p antibody
see all