Recombinant
RabMAb

Anti-Glucose Transporter 8 antibody [EPR9477] (ab169779)

Overview

  • Product name
    Anti-Glucose Transporter 8 antibody [EPR9477]
    See all Glucose Transporter 8 primary antibodies
  • Description
    Rabbit monoclonal [EPR9477] to Glucose Transporter 8
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to residues in Human Glucose Transporter 8 (Uniprot: Q9NY64)

  • Positive control
    • Human cerebellum and fetal heart lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab169779 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Detects a band of approximately 38 kDa (predicted molecular weight: 51 kDa).

There are publications supporting the capability of GLUT8 to migrate at 35 kDa. See PMID 10671487 and 10860996. Thus, full length GLUT8 may migrate between 35-51 kDa.

  • Application notes
    Is unsuitable for ICC/IF,IHC-P or IP.
  • Target

    • Relevance
      Glucose transporter 8 is an insulin-regulated facilitative glucose transporter. It binds cytochalasin B in a glucose-inhibitable manner. It appears to be a dual-specific sugar transporter as it can be inhibited by fructose. It is highly expressed in testis, where it is down-regulated by estrogen, but not in testicular carcinoma. Lower amounts are present in most other tissues.
    • Cellular localization
      Cell Membrane; multi-pass membrane protein. Principally intracellular. May move between intracellular vesicles and the plasma membrane
    • Database links
    • Alternative names
      • Glucose transporter type 8 antibody
      • Glucose transporter type X1 antibody
      • GLUT8 antibody
      • GLUTX1 antibody
      • solute carrier family 2 (facilitated glucose transporter) member 8 antibody
      see all

    Images

    • All lanes : Anti-Glucose Transporter 8 antibody [EPR9477] (ab169779) at 1/1000 dilution

      Lane 1 : Human cerebellum lysate
      Lane 2 : Human fetal heart lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 51 kDa

    References

    This product has been referenced in:
    • Janzen C  et al. Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction. PLoS One 13:e0193583 (2018). Read more (PubMed: 29590129) »
    • Zhang X  et al. Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. Antioxid Redox Signal 22:848-70 (2015). Read more (PubMed: 25602171) »

    See all 2 Publications for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab169779.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up