Recombinant
RabMAb

Anti-Glucose Transporter 8 antibody [EPR9477] (ab169779)

Overview

  • Product name
    Anti-Glucose Transporter 8 antibody [EPR9477]
    See all Glucose Transporter 8 primary antibodies
  • Description
    Rabbit monoclonal [EPR9477] to Glucose Transporter 8
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to residues in Human Glucose Transporter 8 (Uniprot: Q9NY64)

  • Positive control
    • Human cerebellum and fetal heart lysates.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab169779 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Detects a band of approximately 38 kDa (predicted molecular weight: 51 kDa).

There are publications supporting the capability of GLUT8 to migrate at 35 kDa. See PMID 10671487 and 10860996. Thus, full length GLUT8 may migrate between 35-51 kDa.

  • Application notes
    Is unsuitable for ICC/IF,IHC-P or IP.
  • Target

    • Relevance
      Glucose transporter 8 is an insulin-regulated facilitative glucose transporter. It binds cytochalasin B in a glucose-inhibitable manner. It appears to be a dual-specific sugar transporter as it can be inhibited by fructose. It is highly expressed in testis, where it is down-regulated by estrogen, but not in testicular carcinoma. Lower amounts are present in most other tissues.
    • Cellular localization
      Cell Membrane; multi-pass membrane protein. Principally intracellular. May move between intracellular vesicles and the plasma membrane
    • Database links
    • Alternative names
      • Glucose transporter type 8 antibody
      • Glucose transporter type X1 antibody
      • GLUT8 antibody
      • GLUTX1 antibody
      • solute carrier family 2 (facilitated glucose transporter) member 8 antibody
      see all

    Images

    • All lanes : Anti-Glucose Transporter 8 antibody [EPR9477] (ab169779) at 1/1000 dilution

      Lane 1 : Human cerebellum lysate
      Lane 2 : Human fetal heart lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size : 51 kDa

    References

    This product has been referenced in:
    • Zhang X  et al. Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. Antioxid Redox Signal 22:848-70 (2015). Read more (PubMed: 25602171) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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