Anti-Glucose Transporter GLUT1 antibody [SPM498] - C-terminal, prediluted (ab53654)

Overview

  • Product name
    Anti-Glucose Transporter GLUT1 antibody [SPM498] - C-terminal, prediluted
    See all Glucose Transporter GLUT1 primary antibodies
  • Description
    Mouse monoclonal [SPM498] to Glucose Transporter GLUT1 - C-terminal, prediluted
  • Host species
    Mouse
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Glucose Transporter GLUT1 (C terminal).
    Database link: P11166

  • Positive control
    • IHC-P: Human esophagous, breast ductal carcinoma, stomach adenocarcinoma, colon adenocarcinoma, lung adenocarcinoma, ovarian adenocarcinoma, endometrial adenocarcinoma, esophageal squamous cell carcinoma, lung squamous cell carcinoma and bladder transitional cell carcinoma tissues.
  • General notes

    For manual IHC only.

Properties

Applications

Our Abpromise guarantee covers the use of ab53654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1.

Ready to use.

Boil tissue section in Citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.

Primary antibody incubation for 30 minutes at room temperature.

Target

  • Function
    Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
  • Tissue specificity
    Expressed at variable levels in many human tissues.
  • Involvement in disease
    Defects in SLC2A1 are the cause of glucose transporter type 1 deficiency syndrome (GLUT1DS) [MIM:606777]; also known as blood-brain barrier glucose transport defect. This disease causes a defect in glucose transport across the blood-brain barrier. It is characterized by infantile seizures, delayed development, and acquired microcephaly.
    Defects in SLC2A1 are the cause of dystonia type 18 (DYT18) [MIM:612126]. DYT18 is an exercise-induced paroxysmal dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT18 is characterized by attacks of involuntary movements triggered by certain stimuli such as sudden movement or prolonged exercise. In some patients involuntary exertion-induced dystonic, choreoathetotic, and ballistic movements may be associated with macrocytic hemolytic anemia.
  • Sequence similarities
    Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Cell membrane. Melanosome. Localizes primarily at the cell surface (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links
  • Alternative names
    • Choreoathetosis/spasticity episodic (paroxysmal choreoathetosis/spasticity) antibody
    • CSE antibody
    • DYT17 antibody
    • DYT18 antibody
    • DYT9 antibody
    • EIG12 antibody
    • erythrocyte/brain antibody
    • Erythrocyte/hepatoma glucose transporter antibody
    • facilitated glucose transporter member 1 antibody
    • Glucose transporter 1 antibody
    • Glucose transporter type 1 antibody
    • Glucose transporter type 1, erythrocyte/brain antibody
    • GLUT antibody
    • GLUT-1 antibody
    • GLUT1 antibody
    • GLUT1DS antibody
    • GLUTB antibody
    • GT1 antibody
    • GTG1 antibody
    • Gtg3 antibody
    • GTR1_HUMAN antibody
    • HepG2 glucose transporter antibody
    • HTLVR antibody
    • Human T cell leukemia virus (I and II) receptor antibody
    • MGC141895 antibody
    • MGC141896 antibody
    • PED antibody
    • RATGTG1 antibody
    • Receptor for HTLV 1 and HTLV 2 antibody
    • SLC2A1 antibody
    • Solute carrier family 2 (facilitated glucose transporter), member 1 antibody
    • Solute carrier family 2 antibody
    • Solute carrier family 2, facilitated glucose transporter member 1 antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human breast ductal carcinoma tissue stained for Glucose Transporter GLUT1 using ab53654 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human stomach adenocarcinoma tissue stained for Glucose Transporter GLUT1 using ab53654 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human colon adenocarcinoma tissue stained for Glucose Transporter GLUT1 using ab53654 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human lung adenocarcinoma tissue stained for Glucose Transporter GLUT1 using ab53654 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human lung squamous cell carcinoma tissue stained for Glucose Transporter GLUT1 using ab53654 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human ovarian adenocarcinoma tissue stained for Glucose Transporter GLUT1 using ab53654 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human endometrial adenocarcinoma tissue stained for Glucose Transporter GLUT1 using ab53654 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human esophagus tissue stained for Glucose Transporter GLUT1 using ab53654 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human esophageal squamous cell carcinoma tissue stained for Glucose Transporter GLUT1 using ab53654 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human bladder transitional cell carcinoma tissue stained for Glucose Transporter GLUT1 using ab53654 in immunohistochemical analysis.

References

This product has been referenced in:
  • Pizzuti L  et al. GLUT 1 receptor expression and circulating levels of fasting glucose in high grade serous ovarian cancer. J Cell Physiol 233:1396-1401 (2018). Read more (PubMed: 28542798) »
  • Medina Villaamil V  et al. Fructose transporter GLUT5 expression in clear renal cell carcinoma. Oncol Rep 25:315-23 (2011). IHC-P ; Human . Read more (PubMed: 21165569) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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