Overview

  • Product nameAnti-GLUD1 antibody
    See all GLUD1 primary antibodies
  • Description
    Rabbit polyclonal to GLUD1
  • SpecificityDue to high sequence homology with GLUD2 there is a potential for cross-reactivity.
  • Tested applicationsSuitable for: ELISA, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Purified Cow liver Glutamate Dehydrogenase.

  • Positive control
    • Human pancreas tissue

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab116714 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/6000 - 1/24000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use at an assay dependent concentration. Predicted molecular weight: 61 kDa.

Target

  • FunctionMay be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate.
  • Involvement in diseaseDefects in GLUD1 are the cause of familial hyperinsulinemic hypoglycemia type 6 (HHF6) [MIM:606762]; also known as hyperinsulinism-hyperammonemia syndrome (HHS). Familial hyperinsulinemic hypoglycemia [MIM:256450], also referred to as congenital hyperinsulinism, nesidioblastosis, or persistent hyperinsulinemic hypoglycemia of infancy (PPHI), is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. In HHF6 elevated oxidation rate of glutamate to alpha-ketoglutarate stimulates insulin secretion in the pancreatic beta cells, while they impair detoxification of ammonium in the liver.
  • Sequence similaritiesBelongs to the Glu/Leu/Phe/Val dehydrogenases family.
  • Cellular localizationMitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI118167 antibody
    • DHE3_HUMAN antibody
    • EC 1.4.1.3 antibody
    • GDH 1 antibody
    • GDH antibody
    • Gdh-X antibody
    • GDH1 antibody
    • GLUD antibody
    • Glud1 antibody
    • Glud1a antibody
    • Glud1b antibody
    • Gludl antibody
    • Glutamate dehydrogenase (NAD(P)+) antibody
    • Glutamate dehydrogenase 1 antibody
    • Glutamate dehydrogenase 1 mitochondrial antibody
    • Glutamate dehydrogenase 1a antibody
    • Glutamate dehydrogenase 1b antibody
    • Memory-related gene 2 protein antibody
    • MGC127177 antibody
    • MGC132003 antibody
    • MGC80801 antibody
    • MGC93608 antibody
    • mitochondrial antibody
    • MRG-2 antibody
    see all

Anti-GLUD1 antibody images

  • Human Pancreas (formalin fixed, paraffin embedded tissue) stained with ab116714 at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-GLUD1 antibody (ab116714)

ab116714 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab116714.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"