Overview

  • Product nameAnti-GLUD1 antibody (Biotin)
    See all GLUD1 primary antibodies
  • Description
    Rabbit polyclonal to GLUD1 (Biotin)
  • ConjugationBiotin
  • SpecificityDue to high sequence homology with GLUD2 there is a potential for cross-reactivity.
  • Tested applicationsSuitable for: Dot blot, WB, ELISA, Immunomicroscopymore details
  • Species reactivity
    Reacts with: Cow
  • Immunogen

    Full length native protein (purified) corresponding to Cow GLUD1. Full length native protein from Bovine Liver.

Properties

Applications

Our Abpromise guarantee covers the use of ab34810 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot
WB
ELISA
Immunomicroscopy
  • Application notesDot: Use at an assay dependent dilution.
    ELISA: 1/4,000 - 1/20,000.
    IM: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 62 kDa.

    This product has been assayed against 1.0 µg of Glutamate Dehydrogenase in a standard capture ELISA using Peroxidase Conjugated Streptavidin and ABTS as a substrate for 30 minutes at room temperature.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate.
    • Involvement in diseaseDefects in GLUD1 are the cause of familial hyperinsulinemic hypoglycemia type 6 (HHF6) [MIM:606762]; also known as hyperinsulinism-hyperammonemia syndrome (HHS). Familial hyperinsulinemic hypoglycemia [MIM:256450], also referred to as congenital hyperinsulinism, nesidioblastosis, or persistent hyperinsulinemic hypoglycemia of infancy (PPHI), is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. In HHF6 elevated oxidation rate of glutamate to alpha-ketoglutarate stimulates insulin secretion in the pancreatic beta cells, while they impair detoxification of ammonium in the liver.
    • Sequence similaritiesBelongs to the Glu/Leu/Phe/Val dehydrogenases family.
    • Cellular localizationMitochondrion matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • AI118167 antibody
      • DHE3_HUMAN antibody
      • EC 1.4.1.3 antibody
      • GDH 1 antibody
      • GDH antibody
      • Gdh-X antibody
      • GDH1 antibody
      • GLUD antibody
      • Glud1 antibody
      • Glud1a antibody
      • Glud1b antibody
      • Gludl antibody
      • Glutamate dehydrogenase (NAD(P)+) antibody
      • Glutamate dehydrogenase 1 antibody
      • Glutamate dehydrogenase 1 mitochondrial antibody
      • Glutamate dehydrogenase 1a antibody
      • Glutamate dehydrogenase 1b antibody
      • Memory-related gene 2 protein antibody
      • MGC127177 antibody
      • MGC132003 antibody
      • MGC80801 antibody
      • MGC93608 antibody
      • mitochondrial antibody
      • MRG-2 antibody
      see all

    References for Anti-GLUD1 antibody (Biotin) (ab34810)

    ab34810 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab34810.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"