Overview

  • Product nameAnti-GLUD1 antibody (HRP)
    See all GLUD1 primary antibodies
  • Description
    Rabbit polyclonal to GLUD1 (HRP)
  • ConjugationHRP
  • SpecificityAssay by immunoelectrophoresis resulted in a single precipitin arc against anti-peroxidase, anti-Rabbit Serum as well as purified and partially purified Glutamate Dehydrogenase [Bovine Liver].Cross reactivity from other tissues and species may occur but have not been determined. Due to high sequence homology with GLUD2 there is a potential for cross-reactivity.
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with: Cow
  • Immunogen

    Tissue, cells or virus corresponding to Cow GLUD1. Bovine liver Glutamate Dehydrogenase.

Properties

Applications

Our Abpromise guarantee covers the use of ab21142 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
  • Application notesAssayed against 1.0ug of Glutamate Dehydrogenase (Bovine Liver) in a standard capture ELISA using ABTS as a substrate for 30 minutes at room temperature.
    ELISA: 1/1000 - 1/3900.
    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate.
    • Involvement in diseaseDefects in GLUD1 are the cause of familial hyperinsulinemic hypoglycemia type 6 (HHF6) [MIM:606762]; also known as hyperinsulinism-hyperammonemia syndrome (HHS). Familial hyperinsulinemic hypoglycemia [MIM:256450], also referred to as congenital hyperinsulinism, nesidioblastosis, or persistent hyperinsulinemic hypoglycemia of infancy (PPHI), is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. In HHF6 elevated oxidation rate of glutamate to alpha-ketoglutarate stimulates insulin secretion in the pancreatic beta cells, while they impair detoxification of ammonium in the liver.
    • Sequence similaritiesBelongs to the Glu/Leu/Phe/Val dehydrogenases family.
    • Cellular localizationMitochondrion matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • AI118167 antibody
      • DHE3_HUMAN antibody
      • EC 1.4.1.3 antibody
      • GDH 1 antibody
      • GDH antibody
      • Gdh-X antibody
      • GDH1 antibody
      • GLUD antibody
      • Glud1 antibody
      • Glud1a antibody
      • Glud1b antibody
      • Gludl antibody
      • Glutamate dehydrogenase (NAD(P)+) antibody
      • Glutamate dehydrogenase 1 antibody
      • Glutamate dehydrogenase 1 mitochondrial antibody
      • Glutamate dehydrogenase 1a antibody
      • Glutamate dehydrogenase 1b antibody
      • Memory-related gene 2 protein antibody
      • MGC127177 antibody
      • MGC132003 antibody
      • MGC80801 antibody
      • MGC93608 antibody
      • mitochondrial antibody
      • MRG-2 antibody
      see all

    References for Anti-GLUD1 antibody (HRP) (ab21142)

    ab21142 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"