Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S836) antibody (ab119397)

Overview

  • Product name
    Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S836) antibody
    See all Glutamate Receptor 1 (AMPA subtype) primary antibodies
  • Description
    Rabbit polyclonal to Glutamate Receptor 1 (AMPA subtype) (phospho S836)
  • Specificity
    ab119397 detects endogenous levels of Glutamate Receptor 1 (AMPA subtype) only when phosphorylated at serine 836.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic phosphopeptide conjugated to KLH, corresponding to amino acids around phosphorylation site of Serine 836 (

    S-E-Sp-K-R

    ) of Human Glutamate Receptor 1 (AMPA subtype) (NP_000818.2).

  • Positive control
    • Mouse Brain extracts

Properties

Applications

Our Abpromise guarantee covers the use of ab119397 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 102 kDa).

Target

  • Function
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
  • Tissue specificity
    Widely expressed in brain.
  • Sequence similarities
    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
  • Post-translational
    modifications
    Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • Cellular localization
    Cell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2 promotes cell surface expression.
  • Information by UniProt
  • Database links
  • Alternative names
    • GLUR 1 antibody
    • GLUR A antibody
    • AMPA 1 antibody
    • AMPA selective glutamate receptor 1 antibody
    • AMPA-selective glutamate receptor 1 antibody
    • GluA1 antibody
    • GLUH1 antibody
    • GluR K1 antibody
    • GluR-1 antibody
    • GluR-A antibody
    • GluR-K1 antibody
    • GLUR1 antibody
    • GLURA antibody
    • GluRK1 antibody
    • Glutamate receptor 1 antibody
    • Glutamate receptor ionotropic AMPA 1 antibody
    • Glutamate receptor ionotropic antibody
    • Glutamate receptor, ionotropic, AMPA 1 antibody
    • Gria1 antibody
    • GRIA1_HUMAN antibody
    • HBGR1 antibody
    • MGC133252 antibody
    • OTTHUMP00000160643 antibody
    • OTTHUMP00000165781 antibody
    • OTTHUMP00000224241 antibody
    • OTTHUMP00000224242 antibody
    • OTTHUMP00000224243 antibody
    see all

Images

  • All lanes : Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S836) antibody (ab119397) at 1/500 dilution

    Lane 1 : Control
    Lane 2 : Mouse Brain extract


    Predicted band size : 102 kDa
    Observed band size : 106 kDa (why is the actual band size different from the predicted?)

References

This product has been referenced in:
  • Thomas R  et al. Epidermal growth factor prevents APOE4-induced cognitive and cerebrovascular deficits in female mice. Heliyon 3:e00319 (2017). ELISA ; Mouse . Read more (PubMed: 28626809) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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