Anti-Glutamine Synthetase antibody [6/Glutamine Synthetase] (ab125724)

Overview

  • Product nameAnti-Glutamine Synthetase antibody [6/Glutamine Synthetase]
    See all Glutamine Synthetase primary antibodies
  • Description
    Mouse monoclonal [6/Glutamine Synthetase] to Glutamine Synthetase
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Sheep
  • Immunogen

    Full length protein, corresponding to amino acids 1-373 of Sheep Glutamine Synthetase.

  • Positive control
    • Human liver tissue; Human Hepatocellular carcinoma tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab125724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/150 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • FunctionThis enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
  • Involvement in diseaseDefects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.
  • Sequence similaritiesBelongs to the glutamine synthetase family.
  • Developmental stageExpressed during early fetal stages.
  • Cellular localizationCytoplasm. Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • cell proliferation-inducing protein 59 antibody
    • GLNA antibody
    • GLNA_HUMAN antibody
    • GLNS antibody
    • GLUL antibody
    • Glutamate ammonia ligase antibody
    • Glutamate decarboxylase antibody
    • Glutamate--ammonia ligase antibody
    • glutamine synthase antibody
    • Glutamine synthetase antibody
    • GS antibody
    • PIG 43 antibody
    • PIG 59 antibody
    • PIG43 antibody
    • PIG59 antibody
    • Proliferation inducing protein 43 antibody
    see all

Anti-Glutamine Synthetase antibody [6/Glutamine Synthetase] images

  • ab125724 at 1/150 dilution staining Glutamine Synthetase in Paraffin-embedded Human liver tissue by Immunohistochemistry.

References for Anti-Glutamine Synthetase antibody [6/Glutamine Synthetase] (ab125724)

ab125724 has not yet been referenced specifically in any publications.

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