Anti-Glutamine Synthetase antibody [8G9] (ab21256)

Overview

  • Product nameAnti-Glutamine Synthetase antibody [8G9]
    See all Glutamine Synthetase primary antibodies
  • Description
    Mouse monoclonal [8G9] to Glutamine Synthetase
  • SpecificityAb21256 is specific for human Glutamine Synthetase
  • Tested applicationsSuitable for: ELISA, IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant protein (Human) purified from E.coli

  • Positive control
    • Bosc23 cells transfected with mycGS.

Properties

Applications

Our Abpromise guarantee covers the use of ab21256 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
IP Use a concentration of 1 - 2 µg/ml.

Target

  • FunctionThis enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
  • Involvement in diseaseDefects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.
  • Sequence similaritiesBelongs to the glutamine synthetase family.
  • Developmental stageExpressed during early fetal stages.
  • Cellular localizationCytoplasm. Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • cell proliferation-inducing protein 59 antibody
    • GLNA antibody
    • GLNA_HUMAN antibody
    • GLNS antibody
    • GLUL antibody
    • Glutamate ammonia ligase antibody
    • Glutamate decarboxylase antibody
    • Glutamate--ammonia ligase antibody
    • glutamine synthase antibody
    • Glutamine synthetase antibody
    • GS antibody
    • PIG 43 antibody
    • PIG 59 antibody
    • PIG43 antibody
    • PIG59 antibody
    • Proliferation inducing protein 43 antibody
    see all

Anti-Glutamine Synthetase antibody [8G9] images

  • ab21256 staining human Glutamine Synthetase in Bosc23 cell lysates transfected with myc-Glutamine Synthetase by Immunoprecipitation.

    Lane 1: Transfected protein

    Lane 2: Result of precipitates

References for Anti-Glutamine Synthetase antibody [8G9] (ab21256)

ab21256 has not yet been referenced specifically in any publications.

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