Overview

  • Product name
    Anti-Glutaredoxin 2 antibody
    See all Glutaredoxin 2 primary antibodies
  • Description
    Mouse polyclonal to Glutaredoxin 2
  • Host species
    Mouse
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein Human Glutaredoxin 2 (AAH28113)

  • Positive control
    • Lysate from 293T cells transfected with Glutaredoxin 2; HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab167207 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 14 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • Function
    Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
  • Tissue specificity
    Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.
  • Sequence similarities
    Belongs to the glutaredoxin family.
    Contains 1 glutaredoxin domain.
  • Cellular localization
    Mitochondrion and Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2) antibody
    • bA101E13.1 antibody
    • CGI133 antibody
    • Glrx2 antibody
    • GLRX2_HUMAN antibody
    • Glutaredoxin-2 antibody
    • Glutaredoxin-2, mitochondrial antibody
    • GRX2 antibody
    • mitochondrial antibody
    see all

Images

  • All lanes : Anti-Glutaredoxin 2 antibody (ab167207) at 1 µg/ml

    Lane 1 : Lysate from 293T cells transfected with Glutaredoxin 2
    Lane 2 : 293T cell lysate Non-transfected

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 14 kDa

  • Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, labeling Glutaredoxin 2 using ab167207 at 10 µg/ml.

References

ab167207 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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