Anti-Glycine Receptor alpha 3 antibody (ab118924)

Overview

  • Product name
    Anti-Glycine Receptor alpha 3 antibody
    See all Glycine Receptor alpha 3 primary antibodies
  • Description
    Rabbit polyclonal to Glycine Receptor alpha 3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 131-180 (SLDLDPSMLD SIWKPDLFFA NEKGANFHEV TTDNKLLRIF KNGNVLYSIR) of Mouse Glycine Receptor alpha 3 (NP_536686).

  • Positive control
    • Mouse small intestine lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab118924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 56 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
  • Tissue specificity
    Widely distributed throughout the central nervous system.
  • Sequence similarities
    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
  • Domain
    The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of channel inactivation kinetics.
  • Cellular localization
    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • GLRA 3 antibody
    • Glra3 antibody
    • GLRA3_HUMAN antibody
    • Glycine receptor alpha 3 polypeptide antibody
    • Glycine receptor alpha 3 subunit antibody
    • Glycine receptor subunit alpha 3 antibody
    • Glycine receptor subunit alpha-3 antibody
    • Ligand gated ion channel antibody
    see all

Images

  • Anti-Glycine Receptor alpha 3 antibody (ab118924) at 1 µg/ml + Mouse small intestine lysate at 10 µg

    Predicted band size : 56 kDa

References

ab118924 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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