Anti-Glycoprotein VI antibody (ab63925)

Overview

  • Product nameAnti-Glycoprotein VI antibody
    See all Glycoprotein VI primary antibodies
  • Description
    Rabbit polyclonal to Glycoprotein VI
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide surrounding amino acid 319 of human Glycoprotein V1

  • Positive control
    • Jurkat cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 30% Glycerol, 0.5% BSA, PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab63925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 4 µg/ml. Detects a band of approximately 58 kDa.

Target

  • FunctionCollagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.
  • Tissue specificityMegakaryocytes and platelets.
  • Involvement in diseaseBleeding disorder, platelet-type 11
  • Sequence similaritiesContains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Post-translational
    modifications
    N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Glycoprotein 6 antibody
    • Glycoprotein VI antibody
    • GP6 antibody
    • GPIV antibody
    • GPVI antibody
    • GPVI_HUMAN antibody
    • MGC138168 antibody
    • Platelet collagen receptor antibody
    • Platelet glycoprotein VI antibody
    • Platelet glycoprotein VI precursor antibody
    see all

Anti-Glycoprotein VI antibody images

References for Anti-Glycoprotein VI antibody (ab63925)

ab63925 has not yet been referenced specifically in any publications.

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