Anti-Glycoprotein VI antibody (ab82807)

Overview

  • Product nameAnti-Glycoprotein VI antibody
    See all Glycoprotein VI primary antibodies
  • Description
    Rabbit polyclonal to Glycoprotein VI
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 216-265 (PPSPVAEFSE ATAELTVSFT NEVFTTETSR SITASPKESD SPAGPARQYY) of Human GP6 (NP_057447).

  • Positive control
    • Jurkat cell lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab82807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 37 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/1562500.

Target

  • FunctionCollagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.
  • Tissue specificityMegakaryocytes and platelets.
  • Involvement in diseaseBleeding disorder, platelet-type 11
  • Sequence similaritiesContains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Post-translational
    modifications
    N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Glycoprotein 6 antibody
    • Glycoprotein VI antibody
    • GP6 antibody
    • GPIV antibody
    • GPVI antibody
    • GPVI_HUMAN antibody
    • MGC138168 antibody
    • Platelet collagen receptor antibody
    • Platelet glycoprotein VI antibody
    • Platelet glycoprotein VI precursor antibody
    see all

Anti-Glycoprotein VI antibody images

  • Anti-Glycoprotein VI antibody (ab82807) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 37 kDa
    Observed band size : 37 kDa
    Additional bands at : 80 kDa. We are unsure as to the identity of these extra bands.

References for Anti-Glycoprotein VI antibody (ab82807)

ab82807 has not yet been referenced specifically in any publications.

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