Overview

  • Product name
    Glyoxbulin 59
  • Description
    Novel microtubule-targeting agent
  • Biological description

    Novel microtubule-targeting agent. Modified indole-3-glyoxylamide, capable of inhibiting tubulin polymerization and displaying cancer cell cytotoxicity with a well-defined SAR. IC50 for inhibition of tubulin polymerization is 6.6 µM

  • Purity
    > 99%

Properties

  • Chemical name
    N-(6-Isopropoxypyridin-3-yl)-2-(1-(2-methoxyethyl)-1H-indol-3-yl)-2-oxoacetamide
  • Molecular weight
    381.40
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C21H23N3O4
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC(C)Oc1ccc(cn1)NC(=O)C(=O)c3cn(CCOC)c2ccccc23
  • Source

    Synthetic

References

This product has been referenced in:
  • Colley HE  et al. An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer. J Med Chem 58:9309-33 (2015). Read more (PubMed: 26580420) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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