Overview

  • Product name
    GM 6001
  • Description
    Broad spectrum MMP inhibitor
  • Alternative names
    • Galardin
    • ilomastat
  • Biological description

    Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.

  • Purity
    > 98%

Properties

  • Chemical name
    (2R)-N4-Hydroxy-N1-[(1S)-2-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
  • Molecular weight
    388.47
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H28N4O4
  • CAS Number
    142880-36-2
  • PubChem identifier
    132519
  • Storage instructions
    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    ONC(=O)C[C@@H](CC(C)C)C(=O)N[C@@H](Cc2cnc1ccccc12)C(=O)NC
  • Source

    Synthetic

References

This product has been referenced in:
  • Zhang H  et al. Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. Neurotherapeutics 8:206-20 (2011). Read more (PubMed: 21455784) »
  • Levy DE  et al. Matrix metalloproteinase inhibitors: a structure-activity study. J Med Chem 41:199-223 (1998). Read more (PubMed: 9457244) »
  • Grobelny D  et al. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31:7152-4 (1992). Read more (PubMed: 1322694) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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