Anti-GM-CSF Receptor alpha antibody [4H1] (ab95681)

Overview

  • Product nameAnti-GM-CSF Receptor alpha antibody [4H1]
    See all GM-CSF Receptor alpha primary antibodies
  • Description
    Mouse monoclonal [4H1] to GM-CSF Receptor alpha
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human GM-CSF Receptor alpha transfected COS cells.

  • Positive control
    • Human peripheral blood leukocytes

Properties

Applications

Our Abpromise guarantee covers the use of ab95681 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 1µg for 105 cells. Cell number should be determined empirically but can range from 105 to 108 cells/test (based on a test volume of 100 µl).



ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • FunctionLow affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
  • Involvement in diseaseDefects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
  • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 5 subfamily.
  • DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localizationSecreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD_antigen=CD116 antibody
    • CD116 antibody
    • CD116 antigen antibody
    • CDw116 antibody
    • Colony stimulating factor 2 receptor alpha chain antibody
    • Colony stimulating factor 2 receptor alpha low affinity antibody
    • Colony stimulating factor 2 receptor alpha subunit antibody
    • CSF 2R antibody
    • CSF2R antibody
    • CSF2R_HUMAN antibody
    • CSF2RA antibody
    • CSF2RAX antibody
    • CSF2RAY antibody
    • CSF2RX antibody
    • CSF2RY antibody
    • GM CSF R alpha antibody
    • GM CSF receptor alpha subunit antibody
    • GM-CSF-R-alpha antibody
    • GMCSFR antibody
    • GMCSFR-alpha antibody
    • GMR-alpha antibody
    • Granulocyte macrophage colony stimulating factor receptor alpha chain antibody
    • Granulocyte-macrophage colony-stimulating factor receptor subunit alpha antibody
    • SMDP4 antibody
    see all

References for Anti-GM-CSF Receptor alpha antibody [4H1] (ab95681)

ab95681 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"