Overview

  • Product nameAnti-GM2A antibody
    See all GM2A primary antibodies
  • Description
    Goat polyclonal to GM2A
  • Specificityab113440 is expected to recognize isoform 1 (NP_000396.2) only.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse, Rabbit
  • Immunogen

    Synthetic peptide:

    C-TTGNYRIESVLS

    , corresponding to internal sequence amino acids 164-175 of Human GM2A (NP_000396.2).

  • Positive control
    • HEK293 lysate overexpressing Human GM2A with DYKDDDDK tag, Mock-transfected HEK293 lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab113440 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 21 kDa).

Target

  • FunctionBinds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
  • Involvement in diseaseDefects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B.
  • Post-translational
    modifications
    The serines in positions 32 and 33 are absent in 80% of the sequenced protein.
  • Cellular localizationLysosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cerebroside sulfate activator protein antibody
    • ganglioside GM2 activator antibody
    • Ganglioside GM2 activator isoform short antibody
    • Ganglioside GM2 activator precursor antibody
    • GM2 activator antibody
    • GM2 AP antibody
    • GM2 ganglioside activator antibody
    • GM2 ganglioside activator protein antibody
    • GM2-AP antibody
    • GM2A antibody
    • GM2AP antibody
    • OTTHUMP00000160619 antibody
    • SAP 3 antibody
    • SAP-3 antibody
    • SAP3 antibody
    • SAP3_HUMAN antibody
    • Shingolipid activator protein 3 antibody
    • Sphingolipid activator protein 3 antibody
    see all

Anti-GM2A antibody images

  • Anti-GM2A antibody (ab113440) at 0.300000011921 µg/ml + Rat kidney lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 21 kDa
  • Lane 1 : Anti-GM2A antibody (ab113440) at 1 µg/ml
    Lane 2 : Anti-GM2A antibody (ab113440) at 1 mg/ml
    Lane 3 : anti- DYKDDDDK Tag at 1/30000 dilution

    Lane 1 : HEK293 lysate (in RIPA buffer) overexpressing Human GM2A with DYKDDDDK tag
    Lane 2 : Mock-transfected HEK293 lysate (in RIPA buffer)
    Lane 3 : HEK293 lysate (in RIPA buffer) overexpressing Human GM2A with DYKDDDDK tag

    Lysates/proteins at 10 µg per lane.

    Developed using the ECL technique

    Predicted band size : 21 kDa

References for Anti-GM2A antibody (ab113440)

ab113440 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"