Overview

  • Product nameAnti-GMP Synthase antibody
    See all GMP Synthase primary antibodies
  • Description
    Rabbit polyclonal to GMP Synthase
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Chimpanzee, Zebrafish, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 600-650 of Human GMP Synthase (NP_003866.1).

  • Positive control
    • HeLa whole cell lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate
    Note: pH 7 to 8
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab113951 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionInvolved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
    • PathwayPurine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
    • Involvement in diseaseNote=A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with MLL.
    • Sequence similaritiesContains 1 glutamine amidotransferase type-1 domain.
      Contains 1 GMP-binding domain.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • Glutamine amidotransferase antibody
      • GMP synthase [glutamine hydrolyzing] antibody
      • GMP synthase [glutamine-hydrolyzing] antibody
      • GMP synthetase antibody
      • Gmps antibody
      • GUAA_HUMAN antibody
      • Guanine monphosphate synthetase antibody
      • Guanosine 5' monophosphate synthase antibody
      • MLL/GMPS fusion protein antibody
      see all

    Anti-GMP Synthase antibody images

    • Detection of GMP Synthase in Immunoprecipitates of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) using ab113951 at 3 µg/mg lysate for IP. An anti-GMP Synthase antibody which recognizes a downstream epitope was used at 1 µg/ml for subsequent western blot detection. Detection: Chemiluminescence with exposure time of 10 seconds.

    References for Anti-GMP Synthase antibody (ab113951)

    ab113951 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"