The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human Tr alpha, catalog ab3504. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
guanine nucleotide binding protein G(T) alpha 1 subunit
Guanine nucleotide-binding protein G(t) subunit alpha-1
Rod specific transducin
rod-type transducin alpha subunit
Transducin alpha-1 chain
FunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Tissue specificityRod. Predominantly expressed in the retina followed by the ciliary body, iris and retinal pigment epithelium.
Involvement in diseaseNight blindness, congenital stationary, autosomal dominant 3 Night blindness, congenital stationary, 1C
Sequence similaritiesBelongs to the G-alpha family. G(i/o/t/z) subfamily.
Developmental stageExpressed at approximately postnatal day 7.