Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
Expressed in natural killer and T-cells.
Contains 1 saposin B-type domain.
A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.
Secreted. Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.