Overview

  • Product nameAnti-GNMT antibody
    See all GNMT primary antibodies
  • Description
    Mouse polyclonal to GNMT
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human)

  • Positive control
    • Human liver tissue lysate and GNMT transfected 293T cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab67509 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 33 kDa (predicted molecular weight: 33 kDa).

Target

  • FunctionCatalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
  • Tissue specificityAbundant in liver.
  • Involvement in diseaseDefects in GNMT are the cause of glycine N-methyltransferase deficiency (GNMT deficiency) [MIM:606664]; also known as hypermethioninemia. The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.
  • Sequence similaritiesBelongs to the glycine N-methyltransferase family.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 2.1.1.20 antibody
    • Glycine N methyltransferase antibody
    • Glycine N-methyltransferase antibody
    • Gnmt antibody
    • GNMT_HUMAN antibody
    • OTTHUMP00000016412 antibody
    see all

Anti-GNMT antibody images

  • Anti-GNMT antibody (ab67509) at 1/1000 dilution + Human liver tissue lysate at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

    Predicted band size : 33 kDa
    Observed band size : 33 kDa
  • All lanes : Anti-GNMT antibody (ab67509) at 1/500 dilution

    Lane 1 : GNMT transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

    Predicted band size : 33 kDa
    Observed band size : 33 kDa

References for Anti-GNMT antibody (ab67509)

ab67509 has not yet been referenced specifically in any publications.

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