Anti-GNMT antibody - Carboxyterminal end (ab71460)

Overview

  • Product name
    Anti-GNMT antibody - Carboxyterminal end
    See all GNMT primary antibodies
  • Description
    Rabbit polyclonal to GNMT - Carboxyterminal end
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Positive control
    • CEM cell line lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab71460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    ELISA: 1/1000.
    WB: 1/100 - 1/500. Detects bands of approximately 30 and 34 kDa (predicted molecular weight: 33 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
    • Tissue specificity
      Abundant in liver.
    • Involvement in disease
      Defects in GNMT are the cause of glycine N-methyltransferase deficiency (GNMT deficiency) [MIM:606664]; also known as hypermethioninemia. The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.
    • Sequence similarities
      Belongs to the glycine N-methyltransferase family.
    • Cellular localization
      Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • EC 2.1.1.20 antibody
      • Epididymis secretory sperm binding protein Li 182mP antibody
      • Glycine N methyltransferase antibody
      • Glycine N-methyltransferase antibody
      • Gnmt antibody
      • GNMT_HUMAN antibody
      • HEL S 182mP antibody
      • OTTHUMP00000016412 antibody
      see all

    Images

    • Anti-GNMT antibody - Carboxyterminal end (ab71460) at 1/60 dilution + CEM cell line lysate at 35 µg

      Predicted band size : 33 kDa
      Observed band size : 34 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 30 kDa. We are unsure as to the identity of these extra bands.

    References

    ab71460 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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