Overview

  • Product nameAnti-GnRH antibody [LHRH13-327.8]
    See all GnRH primary antibodies
  • Description
    Mouse monoclonal [LHRH13-327.8] to GnRH
  • Specificityab62432 detects GnRH from human samples.
  • Tested applicationsSuitable for: ELISA, IHC-FoFrmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Purified human GnRH.

Properties

Applications

Our Abpromise guarantee covers the use of ab62432 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
IHC-FoFr Use at an assay dependent concentration.

Target

  • RelevanceGonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
  • Cellular localizationSecreted
  • Database links
  • Alternative names
    • GnRH associated peptide 1 antibody
    • GNRH1 antibody
    • Gonadotrophin releasing hormone 1 antibody
    • GRH antibody
    • HH12 antibody
    • LHRH antibody
    • LNRH antibody
    • Luliberin I antibody
    • Luteinizing releasing hormone antibody
    • Lutenizing hormome releasing hormone antibody
    • Progonadoliberin 1 antibody
    • Progonadoliberin I antibody
    • Prolactin release inhibiting factor antibody
    see all

References for Anti-GnRH antibody [LHRH13-327.8] (ab62432)

This product has been referenced in:
  • Roth B  et al. The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus. Drug Target Insights 8:45-50 (2014). Read more (PubMed: 25452692) »
  • Sand E  et al. Structural and functional consequences of buserelin-induced enteric neuropathy in rat. BMC Gastroenterol 14:209 (2014). Read more (PubMed: 25496312) »

See all 3 Publications for this product

Product Wall

We have not tested whether this antibody cross-reacts with GnRH2 however, this antibody is against GnRH1 and GnRH1 only shares 21-22% sequence homology with GnRH2 isforms 1-3 therefore, this antibody is unlikely to recognise GnRH1.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"